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Deterministic-like model reduction for a class of multi-scale stochastic differential equations with application to biomolecular systems (Extended Version)

Herath, Narmada; Del Vecchio, Domitilla (2017-08-01)
Signaling architectures that transmit unidirectional information

Shah, Rushina; Del Vecchio, Domitilla (2016-12-24)

A signaling pathway transmits information from an upstream system to downstream systems, ideally unidirectionally. A key bottleneck to unidirectional transmission is retroactivity, which is the additional reaction flux ...
Controller design under safety specifications for a class of bounded hybrid automata

Hoehener, Daniel; Del Vecchio, Domitilla (IEEE, 2016-12)

Motivated by driver-assist systems that warn the driver before taking control action, we study the safety problem for a class of bounded hybrid automata. We show that for this class there exists a least restrictive safe ...
Mitigation of ribosome competition through distributed sRNA feedback (extended version)

Qian, Yili; Del Vecchio, Domitilla (2016-09-23)

A current challenge in the robust engineering of synthetic gene networks is context dependence, the unintended interactions among genes and host factors. Ribosome competition is a specific form of context dependence, where ...
Hitting time behavior for the solution of a stochastic differential equation

Herath, Narmada; Del Vecchio, Domitilla (2016-09-13)

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