7.340 Ubiquitination: The Proteasome and Human Disease, Fall 2004
Author(s)
Rubio, Marta
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Alternative title
Ubiquitination: The Proteasome and Human Disease
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This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.
Date issued
2004-12Department
Massachusetts Institute of Technology. Department of BiologyOther identifiers
7.340-Fall2004
Other identifiers
7.340
IMSCP-MD5-0d750c82b256819260292e103e872811
Keywords
ubiquitination, ubiquitin, proteasome, post-translational mechanisms, ubiquitin-conjugation system, neurodegenerative diseases, immune response, cell cycle regulation, apoptosis, signal transduction pathways, tumorigenesis, protein degradation, Endoplasmic Reticulum Associated Degradation Pathway, ligases, translocated proteins, misfolded proteins, trafficking membranes, cell cycle control, programmed cell death, Huntington's Disease, Von Hippel-Lindau Disease
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