Students are expected to present topics in class, based on the readings found in the list below. Presentations are based on lectures, readings taken from the primary literature, and class discussions. Some of the topics include loss of memory and other cognitive abilities in normal aging; and neurodegenerative conditions, such as Parkinson's and Alzheimer's diseases.
Students present a short synopsis of the following articles.
Bard, F., C. Cannon, R. Barbour, R. L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, et al. "
Peripherally administered antibodies against amyloid ®-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease."
Nat Med 6(8) (2000): 916-9.
Blanchard, B. J., A. E. Hiniker, C. C. Lu, Y. Margolin, A. S. Yu, and V. M. Ingram. "Elimination of Amyloid ® Neurotoxicity."
J Alzheimers Dis. 2(2) (2000): 137-149.
Blanchard, B. J., G. Konopka, M. Russell, and V. M. Ingram. "
Mechanism and prevention of neurotoxicity caused by ®-amyloid peptides: relation to Alzheimer's disease."
Brain Res. 776(1-2) (1997): 40-50.
Citron, M., T. Oltersdorf, C. Haass, L. McConlogue, A. Y. Hung, P. Seubert, C. Vigo-Pelfrey, I. Lieberburg, and D. J. Selkoe. "
Mutation of the ®-amyloid precursor protein in familial Alzheimer's disease increases ®-protein production."
Nature 360(6405) (1992): 672-4.
Hartley, D. M., D. M. Walsh, C. P. Ye, T. Diehl, S. Vasquez, P. M. Vassilev, D. B. Teplow, and D. J. Selkoe. "
Protofibrillar intermediates of amyloid ® -protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons."
J Neurosci 19(20) (1999): 8876-84.
Morgan, D., et al. "
A ® peptide vaccination prevents memory loss in an animal model of Alzheimer's disease."
Nature 408(6815) (2000): 982-5.
Schenk, D., et al. "
Immunization with amyloid-® attenuates Alzheimerdisease- like pathology in the PDAPP mouse."
Nature 400(6740) (1999): 173-7.
Selkoe. "Part 3: Inhibition of ©-Secretase." 556-564.
Selkoe. "Part 4: Immunological Approach to Therapy." 564-571.
Selkoe. "Part 5: Other Approaches to Therapy." 571-576.
Sherrington, R., E. I. Rogaev, Y. Liang, E. A. Rogaeva, G. Levesque, M. Ikeda, H. Chi, C. Lin, G. Li, K. Holman, et al. "
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease."
Nature 375(6534) (1995 ): 754-60.
Walsh, D. M., I. Klyubin, J. V. Fadeeva, W. K. Cullen, R. Anwyl, M. S. Wolfe, M. J. Rowan, and D. J. Selkoe. "
Naturally secreted oligomers of amyloid ® protein potently inhibit hippocampal long-term potentiation in vivo."
Nature 416(6880) (2002): 535-9.
Yan, R., P. Han, H. Miao, P. Greengard, and H. Xu. "
The transmembrane domain of the Alzheimer's ®-secretase (BACE1) determines its late Golgi localization and access to ®-amyloid precursor protein (APP) substrate."
J Biol Chem. 276(39) (2001) : 36788-96.