This is an archived course. A more recent version may be available at ocw.mit.edu.

Translations*

Calendar

The calendar below provides information on the course's lecture (L) and exam (E) sessions.

SES # TOPICS KEY DATES
I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes
L1 Survey of Clinical Cases of Biomaterials-Tissue Interactions  
L2 Tissue Structures, Unit Cell Processes, and Integrins Homework 1 due
L3 Unit Cell Processes Comprising the Healing Response  
L4 Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs Homework 2 due
L5 Biochemistry of the ECM Homework 3 due
L6 Scaffolds Based on ECM Analogs Used in Organ Synthesis  
L7 Organ Replacement by Induced Regeneration and Tissue Engineering  
L8 Principles and Practice of Tissue Engineering Homework 4 due
E1 Quiz 1  
II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue
L9 Characteristics of the Surfaces of Biomaterials  
L10 Methodology for the Analysis of Surfaces  
L11 Physicochemical Principles of Protein Adsorption on Solid Surfaces Homework 5 due
L12 Protein/Cell/Tissue-Biomaterials Interactions Homework 6 due
L13 Linear vs. Cooperative Cell-Matrix Interactions Homework 7 due
L14 Cell-Matrix Interactions During Spontaneous Healing  
L15 Contraction-Blocking Theory of Regeneration in Adults  
E2 Quiz 2  
III. In Vivo and Clinical Case Studies
L16 Joints and Dental Tissues: Prosthetic Replacement  
L17 Joints and Dental Tissues: Regeneration 1  
L18 Joints and Dental Tissues: Regeneration 2  
L19 Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses  
L20 Rules for Synthesis of Tissues and Organs  
L21 In Vivo Synthesis of Skin Homework 8 due
L22 In Vivo Synthesis of Peripheral Nerves  
L23 In Vivo Synthesis of the Conjunctiva and of Kidney Tissue  
E3 Quiz 3