This is an archived course. A more recent version may be available at ocw.mit.edu.

Readings

Yannas readings are chapters in the course textbook: Buy at Amazon Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.

LEC # TOPICS Readings
I. Unit Cell Processes and Mechanics of Matrix Molecules and Tissues Structures
1 Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms Spector notes (PDF)
2 Tissue Structures and Unit Cell Processes Spector notes (PDF)
3 Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins Spector notes (PDF 1) (PDF 2)

Stossel, Thomas P. "On the Crawling of Animal Cells." Science, New Series, 260, no. 5111 (May 21, 1993): 1086-1094.

Hinz, Boris, Giuseppe Celetta, James J. Tomasek, Giulio Gabbiani, and Christine Chaponnier. "Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity." Molecular Biology of the Cell 12 (September 2001): 2730-2741.

Vale, Ronald D., and Ronald A. Milligan. "The Way Things Move: Looking Under the Hood of Molecular Motor Proteins." Science 288 (April 7, 2000).
4 Models for the Mechanical Behavior of Porous Scaffolds  
5 Structure-Properties Relationships for Tissues  
6 Mechanics of Selected Tissues  
II. Mechanics of Cells: Effects of Exogenous Forces and Endogenous Force Generation
7 Effects of Exogenous Mechanical Forces on Cells Spector notes (PDF)
8 Response of Cells to Substrate Strain Banes, Albert J., Mari Tsuzaki, Juro Yamamoto, Thomas Fischer, Brian Brigman, Thomas Brown, and Larry Miller. "Mechanoreception at the Cellular Level: The Detection, Interpretation, and Diversity of Responses to Mechanical Signals." Biochem Cell Biol 73 (1995): 349-365.

Davies, Peter F., and Satish C. Tripathi. "Mechanical Stress Mechanisms and the Cell - An Endothelial Paradigm." Circulation Research 72, no. 2 (February, 1993): 239-245.

Wang, Ning, James P. Butler, and Donald E. Ingber. "Mechanotransduction Across the Cell Surface and Through the Cytoskeleton." Science, New Series, 260, no. 5111 (May 21, 1993): 1124-1127.

Alenghat, Francis J., and Donald E. Ingber. "Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins." Sciences, STKE (Feb 12, 2002).

Schaffer, Jonathan L., Michael Rizen, Gilbert J. L'Italien, Aziz Benbrahim, Joseph Megerman, Louis C. Gerstenfeld, and Martha L. Gray. "Device for the Application of a Dynamic Biaxially Uniform and Isotropic Strain to a Flexible Cell Culture Membrane." Journal of OrthoPaedic Research 12: 709-719.

McNeil, Paul L., and Richard A. Steinhardt. "Loss, Restoration, and Maintenance of Plasma Membrane Integrity." The Journal of Cell Biology 137, no. 1 (April 7, 1997): 1-4.

McNeil, Paul L., and Richard A. Steinhardt. "Plasma Membrane Disruption: Repair, Prevention, Adaptation." Annu Rev. Cell Dev. Biol. 19 (July 8, 2003): 697-731.

Miyake, Katsuya, and Paul L. McNeil. "Mechanical Injury and Repair of Cells." Crit Care Med 31, no. 8 (Suppl. 2003).
9 Endothelial Cell Response to Flow  
10 Quiz 1  
11 Measuring Cell Contraction

Cell Force Monitor		  
12 Endogenous Mechanical Force Generation by Cells  
13 Models for Cell Contraction In Vitro and In Vivo  
14 Mechanical Coupling of Cells with Matrix Yannas, Chapter 8.
15 Cell-matrix Interactions During Wound Closure Yannas, Chapter 9.
16 Blockade of Contraction During Induced Organ Regeneration Yannas, Chapter 9.
17 Review Oliver, Tim, Juliet Lee, and Ken Jacobson. "Forces Exerted by Locomoting Cells." Cell Biology 5 (1994): 139-147.

Rutherford, Dr. Jack. "Structure and Function of Skeletal Muscle."

Wu, Richard C. "Physiology of smooth muscle."
18 Quiz 2  
III. Tissue Mechanics
19 Review of Principles of Linear Elastic Mechanics Yannas, Chapter 10.
20 Nonlinear Elasticity: Tendon and Skin Yannas, Chapter 11.
21 Linear Viscoelastic Behavior Yannas, Chapter 9.
22 Response of Articular Cartilage to Mechanical Loading  
23 Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc  
24 Mechanical Behavior of Bone  
25 Response of Bone to Mechanical Loading

Review		  
26 Quiz 3