Browsing by Title
Now showing items 43390-43409 of 143233
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Epidermal growth factor receptor-mediated gene delivery : a model system for engineering selective gene therapy approaches
(Massachusetts Institute of Technology, 1998) -
Epidithia-2,5-piperazinediones : total syntheses of the hyalodendrins.
(Massachusetts Institute of Technology, 1979) -
Epigenetic and conventional regulation is distributed among activat= allowing tuning of population-level heterogeneity in its expression
(Public Library of Science, 2009-10)Epigenetic switches encode their state information either locally, often via covalent modification of DNA or histones, or globally, usually in the level of a trans-regulatory factor. Here we examine how the regulation of ... -
Epigenetic and Conventional Regulation Is Distributed among Activators of FLO11 Allowing Tuning of Population-Level Heterogeneity in Its Expression
(Public Library of Science, 2009-10)Epigenetic switches encode their state information either locally, often via covalent modification of DNA or histones, or globally, usually in the level of a trans-regulatory factor. Here we examine how the regulation of ... -
Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
(Massachusetts Institute of Technology, 2014)Transmission of information from DNA to RNA to protein underlies the core of modem life forms. The advance in sequencing and genetic technologies has revolutionized the study of molecular biology, genetics and developmental ... -
An epigenetic blockade of cognitive functions in the neurodegenerating brain
(Nature Publishing Group, 2012-02)Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central nervous system, including Alzheimer’s disease [superscript 1]. The causes leading to such impairment are only poorly understood ... -
Epigenetic cell memory: The gene’s inner chromatin modification circuit
(Public Library of Science (PLoS), 2022-04)<jats:p>Epigenetic cell memory allows distinct gene expression patterns to persist in different cell types despite a common genotype. Although different patterns can be maintained by the concerted action of transcription ... -
Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome
(Public Library of Science, 2011-10)Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. In addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social difficulties, anxiety, and other ... -
An epigenetic clock controls aging
(Springer Netherlands, 2015-11)We are accustomed to treating aging as a set of things that go wrong with the body. But for more than twenty years, there has been accumulating evidence that much of the process takes place under genetic control. We have ... -
Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria
(Proceedings of the National Academy of Sciences, 2020)© 2020 National Academy of Sciences. All rights reserved. Phosphorothioate (PT) DNA modifications-in which a nonbonding phosphate oxygen is replaced with sulfur-represent a widespread, horizontally transferred epigenetic ... -
Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria
(Proceedings of the National Academy of Sciences, 2020)© 2020 National Academy of Sciences. All rights reserved. Phosphorothioate (PT) DNA modifications-in which a nonbonding phosphate oxygen is replaced with sulfur-represent a widespread, horizontally transferred epigenetic ... -
Epigenetic determinants of cellular differentiation, transcriptional reprogramming, and human disease
(Massachusetts Institute of Technology, 2020)Much of the diversity we observe in cellular and organismal phenotypes can be attributed to epigenetic and genetic variation. DNA provides the instructions for life, while epigenetic modifications regulate which parts of ... -
Epigenetic dynamics during flowering plant reproduction: evidence for reprogramming?
(Wiley, 2019-05)Over the last 10 yr there have been major advances in documenting and understanding dynamic changes to DNA methylation, small RNAs, chromatin modifications and chromatin structure that accompany reproductive development ... -
Epigenetic memory in induced pluripotent stem cells
(Nature Publishing Group, 2010-07)Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, ... -
Epigenetic Memory of Mouse Intestinal Inflammation
(Massachusetts Institute of Technology, 2021)The gut, encompassing one of the largest epithelial surfaces in the body, interacts with both biological and non-biological agents that can cause regular injury. Fortunately, the small intestinal epithelium has a remarkable ... -
Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease
(Bentham Science, 2017-12)Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling ... -
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
(Elsevier, 2014-01)Traumatic events generate some of the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most ... -
Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer
(Impact Journals, 2011-12)The Notch signaling pathway drives proliferation, differentiation, apoptosis, cell fate, and maintenance of stem cells in several tissues. Aberrant activation of Notch signaling has been described in several tumours and ... -
An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
(Elsevier B.V., 2011-05)Constitutive heterochromatin is traditionally viewed as the static form of heterochromatin that silences pericentromeric and telomeric repeats in a cell cycle- and differentiation-independent manner. Here, we show that, ... -
Epigenetic stability in the adult mouse cortex under conditions of pharmacologically induced histone acetylation
(Springer Berlin Heidelberg, 2015-11)Histone acetylation is considered a major epigenetic process that affects brain development and synaptic plasticity, as well as learning and memory. The transcriptional effectors and morphological changes responsible for ...
