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In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration
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In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration
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Name
nihms-1543715.pdf
Description
Accepted version
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2.19 MB
Format
Adobe PDF
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sword-2020-11-12T19:26:20.original.xml (130 B)
Original SWORD entry document
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Author(s)
Sangaré, Lamba Omar
•
Ólafsson, Einar B
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Wang, Yifan
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Yang, Ninghan
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Julien, Lindsay
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Camejo, Ana
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Pesavento, Patricia
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Sidik, Saima M
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Lourido, Sebastian
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Barragan, Antonio
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Journal
Cell Host and Microbe
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2019 Elsevier Inc. Sangaré et al. use a CRISPR screen to determine the in vivo fitness of Toxoplasma genes. They identify a secreted protein, TgWIP, which determines dendritic cell motility and transmigration in the infected host. In mice, TgWIP determines T. gondii dissemination from the site of infection to distant organs.
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Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Persistent DSpace Link
https://hdl.handle.net/1721.1/132590
DOI of Published Version
10.1016/J.CHOM.2019.09.008
