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Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator
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Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator
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Name
nihms-1599109.pdf
Description
Accepted version
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3.32 MB
Format
Adobe PDF
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sword-2021-08-13T13:56:09.original.xml (130 B)
Original SWORD entry document
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Date Issued
2020
Journal
Neuron
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. One-photon fluorescent imaging of calcium signals can capture the activity of hundreds of neurons across large fields of view but suffers from crosstalk from neuropil. Shemesh et al. engineer cell-body-targeted variants of fluorescent calcium indicators and show in mice and zebrafish that artifactual spikes and correlations are greatly reduced.
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Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Persistent DSpace Link
https://hdl.handle.net/1721.1/133248
DOI of Published Version
10.1016/J.NEURON.2020.05.029
