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Are redox changes a critical switch for mitotic progression?
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Are redox changes a critical switch for mitotic progression?
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KMCO_7_1832419.pdf
Description
Published version
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1.03 MB
Format
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sword-2021-08-04T15:14:02.original.xml (130 B)
Original SWORD entry document
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Author(s)
Lim, Daniel C
•
Joukov, Vladimir
•
Yaffe, Michael B
Date Issued
2020
Journal
Molecular and Cellular Oncology
Publisher
Informa UK Limited
Version
Final published version
Abstract
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
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Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Persistent DSpace Link
https://hdl.handle.net/1721.1/134407
DOI of Published Version
10.1080/23723556.2020.1832419
