Skip to main content
We are experiencing minor difficulties with our submission forms, which we are working to resolve. If you have any issues while submitting items, please contact us at dspace-lib@mit.edu.
Log in
(current)
MIT Open Scholarship
DSpace@MIT
Search
Home
MIT Open Access Articles
MIT Open Access Articles
Are redox changes a critical switch for mitotic progression?
This is not the latest version of this item. The latest version can be found
here
.
Are redox changes a critical switch for mitotic progression?
Download
Name
KMCO_7_1832419.pdf
Description
Published version
Show more
Size
1.03 MB
Format
Adobe PDF
Checksum
(MD5)
04f5a41bc2b755a688ede2ef0df361da
Show more
sword-2021-08-04T15:14:02.original.xml (130 B)
Original SWORD entry document
Show more
Author(s)
Lim, Daniel C
•
Joukov, Vladimir
•
Yaffe, Michael B
Date Issued
2020
Journal
Molecular and Cellular Oncology
Publisher
Informa UK Limited
Version
Final published version
Abstract
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
Show more
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
http://creativecommons.org/licenses/by-nc-nd/4.0/
Persistent DSpace Link
https://hdl.handle.net/1721.1/134407
DOI of Published Version
10.1080/23723556.2020.1832419
