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Polymeric Nanoparticles Active against Dual-Species Bacterial Biofilms
Name
molecules-26-04958.pdf
Size
2.85 MB
Format
Adobe PDF
Checksum (MD5)
0d394f8041dafd3bac349f2e8b5e541d
Author(s)
Makabenta, Jessa Marie V.
Park, Jungmi
Li, Cheng-Hsuan
Chattopadhyay, Aritra Nath
Nabawy, Ahmed
Landis, Ryan F.
Gupta, Akash
Schmidt-Malan, Suzannah
Patel, Robin
Rotello, Vincent M.
Date Issued
August 16, 2021
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Molecules 26 (16): 4958 (2021)
Version
Final published version
Abstract
Biofilm infections are a global public health threat, necessitating new treatment strategies. Biofilm formation also contributes to the development and spread of multidrug-resistant (MDR) bacterial strains. Biofilm-associated chronic infections typically involve colonization by more than one bacterial species. The co-existence of multiple species of bacteria in biofilms exacerbates therapeutic challenges and can render traditional antibiotics ineffective. Polymeric nanoparticles offer alternative antimicrobial approaches to antibiotics, owing to their tunable physico-chemical properties. Here, we report the efficacy of poly(oxanorborneneimide) (PONI)-based antimicrobial polymeric nanoparticles (PNPs) against multi-species bacterial biofilms. PNPs showed good dual-species biofilm penetration profiles as confirmed by confocal laser scanning microscopy. Broad-spectrum antimicrobial activity was observed, with reduction in both bacterial viability and overall biofilm mass. Further, PNPs displayed minimal fibroblast toxicity and high antimicrobial activity in an in vitro co-culture model comprising fibroblast cells and dual-species biofilms of Escherichia coli and Pseudomonas aeruginosa. This study highlights a potential clinical application of the presented polymeric platform.
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Creative Commons Attribution
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DOI of Published Version
http://dx.doi.org/10.3390/molecules26164958
