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Electrical bioadhesive interface for bioelectronics
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137.pdf
Description
Accepted version
Size
9.84 MB
Format
Adobe PDF
Checksum (MD5)
699ef26840854472eb1c927081387593
Author(s)
Deng, Jue
Yuk, Hyunwoo
Wu, Jingjing
Varela, Claudia E
Chen, Xiaoyu
Roche, Ellen T
Guo, Chuan Fei
Zhao, Xuanhe
Date Issued
2021
Journal
Nature Materials
Publisher
Springer Science and Business Media LLC
Citation
Deng, Jue, Yuk, Hyunwoo, Wu, Jingjing, Varela, Claudia E, Chen, Xiaoyu et al. 2021. "Electrical bioadhesive interface for bioelectronics." Nature Materials, 20 (2).
Version
Author's final manuscript
Abstract
© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Reliable functions of bioelectronic devices require conformal, stable and conductive interfaces with biological tissues. Integrating bioelectronic devices with tissues usually relies on physical attachment or surgical suturing; however, these methods face challenges such as non-conformal contact, unstable fixation, tissue damage, and/or scar formation. Here, we report an electrical bioadhesive (e-bioadhesive) interface, based on a thin layer of a graphene nanocomposite, that can provide rapid (adhesion formation within 5 s), robust (interfacial toughness >400 J m−2) and on-demand detachable integration of bioelectronic devices on diverse wet dynamic tissues. The electrical conductivity (>2.6 S m−1) of the e-bioadhesive interface further allows bidirectional bioelectronic communications. We demonstrate biocompatibility, applicability, mechanical and electrical stability, and recording and stimulation functionalities of the e-bioadhesive interface based on ex vivo porcine and in vivo rat models. These findings offer a promising strategy to improve tissue–device integration and enhance the performance of biointegrated electronic devices.
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DOI of Published Version
10.1038/S41563-020-00814-2
