We are experiencing minor difficulties with our submission forms, which we are working to resolve. If you have any issues while submitting items, please contact us at dspace-lib@mit.edu.

Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation

Thumbnail Image
Download
Name

nihms-1679388.pdf

Description
Accepted version
Size

943.59 KB

Format

Adobe PDF

Checksum (MD5)

faa028b85c988e9a9b0dc05e4642cc4b

sword-2022-02-14T18:52:34.original.xml (130 B)
Original SWORD entry document
Author(s)
Rodriguez, Jacob
•
Dhanjee, Heemal H
•
Buchwald, Stephen L
Date Issued
2021
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Rodriguez, Jacob, Dhanjee, Heemal H and Buchwald, Stephen L. 2021. "Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation." Organic Letters, 23 (3).
Version
Author's final manuscript
Abstract
© 2021 American Chemical Society. Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
10.1021/ACS.ORGLETT.0C04001
PrivacyPermissionsAccessibilityContact us
Notify us about copyright concerns.