Biomaterials for non-viral delivery of nucleic acid drugs

Abstract

Significant progress has been made in the field of biomaterials for non-viral delivery of macromolecules. A wide variety of distinct types of novel biomaterials, in combination with corresponding cutting-edge therapeutic systems and technologies, have been developed and have shown highly promising therapeutic efficacies in research studies published. Furthermore, a number of these technologies are rapidly progressing to and through clinical trial. Specifically, substantial progress related to the development of drug delivery technologies including lipid nanoparticulate formulations, polymer nanoparticulate formulations, and other types of nanoparticulate formulations may lead to the development of substantial libraries of novel, highly effective, next-generation therapeutic technologies. The motivation of this thesis is to review these state-of-the-art technologies.