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Promoter directionality is controlled by U1 snRNP and polyadenylation signals in mouse embryonic stem cells
(Massachusetts Institute of Technology, 2013)
RNA polymerase II (RNAPII) transcription is a tightly regulated process controlling cell type and state. Advancements in our understanding of how transcription is regulated will provide insight into the mechanisms controlling ...
Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
(Massachusetts Institute of Technology, 2013)
The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...
Consequences of redox-active phenazines on the physiology of the opportunistic pathogen Pseudomonas aeruginosa
(Massachusetts Institute of Technology, 2013)
Phenazines are redox-active small molecules produced by bacteria. Although phenazines have been studied extensively for their roles as toxins, how phenazines benefit producing organisms is still being uncovered. Pseudomonas ...
Aberrant Ras/MAPK signaling in skeletal development
(Massachusetts Institute of Technology, 2013)
The Mitogen-activated protein kinase(MAPK) signaling pathway has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have ...
Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts
(Massachusetts Institute of Technology, 2013)
Co-evolution of pathogen and host helps drive biological diversity. Unlike viral-host interactions, little is known about the co-evolution of eukaryotic pathogens with their hosts. The intracellular parasite Toxoplasma ...
Global analysis of the transcriptional regulation of Sinorhizobium meliloti cell cycle progression and study of cell cycle regulation during symbiosis with Medicago sativa
(Massachusetts Institute of Technology, 2013)
The complex [alpha]-proteobacterial cell cycle regulatory network is essential not only for faithful replication and segregation of the genome, but also to coordinate unique cellular differentiation events that have evolved ...
Transcript leaders : annotation and insight into functions in translation
(Massachusetts Institute of Technology, 2013)
For a eukaryotic mRNA to be properly expressed, it undergoes a series of several steps, including transcription, modification, splicing, packaging, export, localization, translation, and decay. Of these steps transcription ...
Amino acid regulation of mTORC1
(Massachusetts Institute of Technology, 2013)
Mammalian target of rapamycin complex I (mTORC1) is an atypical Ser/Thr kinase that regulates cellular and organismal growth. Accordingly, mTORC1 has substantial roles in regulating insulin sensitivity and lifespan, and ...
Specificity and evolution of bacterial two-component signal transduction systems
(Massachusetts Institute of Technology, 2013)
Cells possess a remarkable capacity to sense and process a diverse range of signals. Duplication and divergence of a relatively small number of gene families has provided the raw material enabling cells to quickly increase ...
The role of the N domain in substrate binding, oligomerization, and allosteric regulation of the AAA+ Lon protease
(Massachusetts Institute of Technology, 2013)
For cells and organisms to survive, they must maintain protein homeostasis in varied and often harsh environments. Cells utilize proteases and chaperones to maintain their proteomes. In bacteria, most cytosolic proteolysis ...