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Now showing items 21-30 of 39
A meiosis-specific form of the Anaphase Promoting Complex/Cyclosome regulates the oocyte-to-embryo transition in Drosophila
(Massachusetts Institute of Technology, 2013)
Cell cycle transitions during mitosis and meiosis must proceed in an irreversible manner. At the heart of this is the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. The APC/C targets its substrates ...
Deep explosive volcanism on the Gakkel Ridge and seismological constraints on Shallow Recharge at TAG Active Mound
(Massachusetts Institute of Technology, 2013)
Seafloor digital imagery and bathymetric data are used to evaluate the volcanic characteristics of the 85°E segment of the ultraslow spreading Gakkel Ridge (9 mm yr-¹). Imagery reveals that ridges and volcanic cones in the ...
Microdomain calcium oscillations in Drosophila glia regulate seizure susceptibility and require NCKX
(Massachusetts Institute of Technology, 2013)
Glial cells exhibit spontaneous and activity-dependent fluctuations in intracellular Ca²+, yet it is unclear whether glial Ca²+ oscillations are required during neuronal signaling. Somatic glial Ca²+ waves are primarily ...
Investigation of the structure requirements for oligosaccharyl transferase function
(Massachusetts Institute of Technology, 2013)
N-linked glycosylation is a ubiquitous protein modification involved in a wide range of cellular functions and diseases (Varki, 1993). The oligosaccharyl transferase (OTase), the principle enzyme responsible for catalysis ...
Using chemical biology as a tool to probe the mechanism of the HDL receptor
(Massachusetts Institute of Technology, 2013)
The high density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), is a cell surface glycoprotein that controls HDL structure and metabolism by mediating cellular selective uptake of lipids from HDL. ...
An investigation of the roles of geomagnetic and acoustic cues in whale navigation and orientation
(Massachusetts Institute of Technology, 2013)
Many species of whales migrate annually between high-latitude feeding grounds and low-latitude breeding grounds. Yet, very little is known about how these animals navigate during these migrations. This thesis takes a first ...
Molecular mechanisms of regeneration initiation and dorsal-ventral patterning in planarians
(Massachusetts Institute of Technology, 2013)
Regeneration is widespread among animals, yet very little is known about the molecular mechanisms that govern regenerative processes. Planarians have emerged in recent years as a powerful model for studying regeneration ...
Mechanistic studies of a AAA+ protease
(Massachusetts Institute of Technology, 2013)
AAA+ proteases are present in all branches of life and responsible for the energy-dependent degradation of most cytosolic proteins. Substrates for AAA+ proteases are unfolded and translocated into a compartmental peptidase. ...
Modeling disease-related proteins in Saccharomyces cerevisiae : insights into alpha-synuclein and TorsinA biology
(Massachusetts Institute of Technology, 2013)
The yeast Saccharomyces cerevisiae has long been used to model complex cellular processes. As a eukaryote, much of its fundamental biology is conserved with higher organisms. As a single-celled, genetically tractable ...
Regulatory pathways controlling cell division after DNA damage in Caulobacter crescentus
(Massachusetts Institute of Technology, 2013)
All cells must coordinate DNA replication with cell division in order to faithfully propagate whole chromosomes to daughter cells. During episodes of DNA damage, cells often delay division until the lesions have been ...