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Now showing items 11-20 of 1071
Population dynamics and diversity of Synechococcus on the New England shelf
(Massachusetts Institute of Technology, 2014)
Synechococcus is a ubiquitous marine primary producer. Our understanding of the factors that determine its abundance has been limited by available observational tools, which have not been able to resolve population dynamics ...
2', 3' isomeric specificity at the C-C-A end of tRNA during aminoacylation and protein synthesis.
(Massachusetts Institute of Technology, 1975)
Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
(Massachusetts Institute of Technology, 2013)
The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...
Coordinated regulation of glycolysis and the folate one-carbon cycle
(Massachusetts Institute of Technology, 2015)
Rapid cell proliferation is characteristic of many biological systems, including cancer, normal development, and immune responses. At a basic level, proliferation requires that a cell synthesize a new copy of itself, with ...
RNA polymerase II holoenzyme components and regulation
(Massachusetts Institute of Technology, 1999)
Genetic analysis of endoplasmic reticulum homeostasis during stress and infection of Caenorhabditis elegans
(Massachusetts Institute of Technology, 2018)
Animals experience intrinsic and extrinsic stressors throughout development and adulthood. To maintain cellular and organismal homeostasis, eukaryota and metazoa rely on conserved, integrated stress response pathways. ...
Mena 11a-isoform specific regulation of actin cytoskeleton organization and cell behavior
(Massachusetts Institute of Technology, 2016)
EnaNASP proteins are a conserved family of actin regulatory proteins that modulate cell motility and morphology by altering actin dynamics. Mena, an EnaNASP protein, is alternatively spliced, producing protein isoforms ...
Functions of the conserved ribosome-bound protein Lso2 in translation and physiology
(Massachusetts Institute of Technology, 2017)
The ribosome is a highly conserved macromolecular machine that carries out translation, the synthesis of proteins from mRNAs, in all domains of life. The core ribosome interacts with dozens of general translation factors ...
Insights into the consequences of chromosome gains and losses in S. cerevisiae
(Massachusetts Institute of Technology, 2016)
When cells divide, they must properly duplicate and segregate their genome to generate two identical daughter cells with faithful transmission of the genomic content. Errors in chromosome segregation lead to aneuploidy, a ...
The role of dosage sensitive genes in aneuploid phenotypes
(Massachusetts Institute of Technology, 2016)
Aneuploidy-the gain or loss of one or more whole chromosomes-typically has an adverse impact on organismal fitness, manifest in conditions such as Down syndrome. A central question is whether aneuploid phenotypes are the ...