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Now showing items 11-20 of 248
The hippocampal "Event Code" : implications from Descartes to Gridworld
(Massachusetts Institute of Technology, 2020)
The brain codes continuous spatial, temporal, and sensory changes in daily experience. Recent studies suggest the brain also tracks experience as segmented subdivisions (events), but the neural basis for encoding events ...
Activity-dependent integration and plasticity of new neurons during postnatal neurogenesis
(Massachusetts Institute of Technology, 2010)
Most neurons are born during the embryonic period to become the building blocks for a variety of brain circuits. However, two brain regions only start to assemble during the postnatal period. Both brain areas, olfactory ...
Mapping spatial relations
(Massachusetts Institute of Technology, 2004)
One of the fundamental issues in cognitive science is the problem of grounding concepts in the perceptual world. In this thesis, I present a computational theory for how spatial relations are grounded in the perceptual ...
Critical window in autism : a study on Shank3
(Massachusetts Institute of Technology, 2016)
Autism and autism spectrum disorders (ASDs) are clinically defined by the symptoms of social impairment and repetitive behavior, affecting 1 in 68 children in the United States. Because patients with ASDs typically display ...
Dynamics of dopamine signaling and network activity in the striatum during learning and motivated pursuit of goals
(Massachusetts Institute of Technology, 2013)
Learning to direct behaviors towards goals is a central function of all vertebrate nervous systems. Initial learning often involves an exploratory phase, in which actions are flexible and highly variable. With repeated ...
Unsupervised learning of invariant object representation in primate visual cortex
(Massachusetts Institute of Technology, 2011)
Visual object recognition (categorization and identification) is one of the most fundamental cognitive functions for our survival. Our visual system has the remarkable ability to convey to us visual object and category ...
The role of real-world size in object representation
(Massachusetts Institute of Technology, 2011)
Every object in the world has a physical size which is intrinsic to how we interact with it: we pick up small objects like coins with our fingers, we throw footballs and swing tennis rackets, we orient our body to bigger ...
The temporal and bilateral structure of hippocampal replay
(Massachusetts Institute of Technology, 2013)
The hippocampus is required for the formation, but not storage, of long-term episodic memories. During memory formation, however, the hippocampus is not a lone actor; rather it works in concert with various structures ...
CaMKII at a central synapse : α-calcium/calmodium protien kinase II and synaptic plasticity at CA3 Schaffer collateral -- CA1 synapses in the mammalian hippocampus
(Massachusetts Institute of Technology, 2001)
Long term potentiation (LTP) of synaptic transmission at the CA3-CA1 hippocampal synapse is a model synaptic plasticity mechanism that may underlie hippocampal dependent learning and memory. Inhibition of post-synaptic ...
Neural responses to relative motion in V1 and V2 of macaque monkeys
(Massachusetts Institute of Technology, 2001)
Relative motion information is required for solving many complex visual tasks, such as depth perception by motion parallax and motion-induced figure/ground segmentation. However, little is known about the neural substrate ...