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Integrative multi-omics dissection of cancer cell states and susceptibility
(Massachusetts Institute of Technology, 2021)
Cancer cells are characterized by a broad spectrum of unique genetic, epigenetic and transcriptional states, which are often concomitant with high degrees of plasticity in cell identity. These cell states and the fluidity ...
The influence of mucin glycans on microbial virulence and competition
(Massachusetts Institute of Technology, 2021)
The human body is colonized by trillions of microbes, many of which reside in a layer of mucus that covers all wet epithelia in the body. In this way, mucus serves as the first line of defense to the host, simultaneously ...
Effects of the mobile genetic element ICEBs1 on bacterial host fitness
(Massachusetts Institute of Technology, 2020)
Mobile genetic elements drive bacterial evolution by mediating horizontal gene transfer and by carrying cargo genes that confer important traits to host cells. Traits provided by mobile genetic elements include antibiotic ...
Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
(Massachusetts Institute of Technology, 2020)
Structural and functional plasticity induced by neuronal competition is a common feature of developing nervous systems. However, the rules governing how postsynaptic cells differentiate between presynaptic inputs are ...
Investigating brain-wide neural mechanisms using fMRI and novel tools
(Massachusetts Institute of Technology, 2020)
Defining the neural mechanisms that coordinate behavior requires characterizing the activity dynamics of diverse brain regions and neural circuit elements. My thesis explores such dynamics to help understand brain-wide ...