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Nanoscale and microscale approaches for engineering the in vitro cellular microenvironment
(Massachusetts Institute of Technology, 2005)
Micro- and nanofabrication approaches have dramatically changed our society through their use in microelectronics and telecommunication industries. These engineering tools are also useful for many biological applications ...
Cartilage mechanobiology : the effects of loading on the fine structure and function of chondroitin sulfate glycosaminoglycans
(Massachusetts Institute of Technology, 2005)
Chondroitin sulfate is a critical component of articular cartilage due to its contribution to the tissue's resistance to compressive deformation. Alterations in the biosynthesis of this molecule over time could impact the ...
Nucleobase deamination as a biomarker of inflammatory processes
(Massachusetts Institute of Technology, 2005)
(cont.) kinetic studies. Moderate increases ([approximately]30%) in nucleobase deamination products were observed in the SJL mice bearing the RcsX tumor, but the biological meaning of these increases awaits studies of DNA ...
Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage
(Massachusetts Institute of Technology, 2005)
The mechanical properties of articular cartilage are associated with the extracellular matrix network of type II collagen and the proteoglycan, aggrecan, which in combination provide the tensile, shear, and compressive ...
Quantitative analysis of the cytokine-mediated apoptosis-survival cell decision process
(Massachusetts Institute of Technology, 2005)
How do cells sense their environment and decide whether to live or to die? This question has drawn considerable interest since 1972, when it was first discovered that cells have an intrinsic ability to self-destruct through ...
Glycosaminoglycan regulation of cell function
(Massachusetts Institute of Technology, 2005)
Glycosaminoglycans (GAGs) are complex polysaccharides that exist both on the cell surface and free within the extracellular matrix. The intrinsic sequence variety stemming from the large number of building blocks that ...
Molecular pathogenesis of Helicobacter hepaticus induced liver disease
(Massachusetts Institute of Technology, 2005)
Helicobacter hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions ...
Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction
(Massachusetts Institute of Technology, 2005)
Chondrocytes respond to in vivo mechanical loads by regulating the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo ...
Cisplatin cytotoxicity associated with tetracycline resistance determinants in Escherichia coli
(Massachusetts Institute of Technology, 2005)
Tetracyclines, a broad-spectrum class of antibiotics, were discovered in the late 1940s, and became widely used because of their important advantages: they are inexpensive, safe, demonstrate good oral absorption, and are ...
Molecular recognition of chlorine-doped polypyrrole
(Massachusetts Institute of Technology, 2005)
The objective of this work is to functionalize an existing polymer such that it better mimics natural tissue for tissue growth and regeneration. Numerous other processes have tried and accomplished this by non-specific ...