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Reagent usage optimization In high volume diagnostics testing
(Massachusetts Institute of Technology, 2018)
Company X provides healthcare diagnostics testing services. The company competes in the market by providing cost effective, short turn-around-time (TAT) solutions and a large variety of test selections. Reducing operating ...
Improving predictability of cell culture processes during biologics manufacturing scale-up through hybrid modeling
(Massachusetts Institute of Technology, 2020)
In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large-scale production bioreactors (15,000L), but process development occurs in lab-scale production bioreactors (2-3L). Cell culture ...
Evaluation of automated storage and retrieval in a distribution center
(Massachusetts Institute of Technology, 2020)
In the face of e-commerce growth and rising customer delivery expectations, companies must adapt to meet shorter contract shipping requirements with existing infrastructures. The "Amazon effect", an evolution resulting in ...
Reducing variations in a highly constrained environment in order to increase production capacity
(Massachusetts Institute of Technology, 2020)
Variations and the negatives effects it causes on production capacity and planning are topics of significant interest in the manufacturing communities. This research investigates the hypothesis that, when operating in a ...
Value of distribution-level reactive power for combined heat and power systems
(Massachusetts Institute of Technology, 2020)
As the U.S. electric grid continues to experience an increase in the penetration of distributed energy resources (DER), electric utilities are evaluating new approaches for utilizing DER to help cost-effectively maintain ...
Optimizing inbound freight mode decisions
(Massachusetts Institute of Technology, 2020)
Retail manufacturers often expedite inbound freight shipments from contract manufacturing bases to their distribution centers in destination markets at high cost to improve service levels to their wholesale partners and ...
Artificial intelligence infrastructure into material attributes insights
(Massachusetts Institute of Technology, 2020)
The development of a biopharmaceutical manufacturing process involves an assessment of all possible sources of variation throughout each of the unit operations in the drive toward six sigma manufacturing. The primary goal ...
Increasing e-commerce distribution center capacity through slotting strategy
(Massachusetts Institute of Technology, 2020)
To meet increasing consumer expectations around delivery times, ecommerce retailers must take orders from 'click' to 'ship' as soon as possible. For retailers with tens of thousands of stock keeping units (SKUs), item ...
Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development
(Massachusetts Institute of Technology, 2020)
A critical early step in the development of a new biopharmaceutical is the selection of the master cell bank. Per FDA requirements, the same master cell bank must be used for all toxicity and clinical trials, as well as ...
Inventory modeling for active pharmaceutical ingredient supply chains
(Massachusetts Institute of Technology, 2020)
Pharmaceutical companies traditionally manufactured drugs in-house, and have only recently been increasingly outsourcing production to contract manufacturing organizations (CMOs). In this work, we use inventory modeling ...