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Now showing items 31-40 of 101
Quantitation of 8-oxoG and strand breaks in pUC19 plasmid DNA after exposure to oxygen radical generating systems
(Massachusetts Institute of Technology, 1995)
A novel bioengineering platform using functionalized self-assembly peptides to enhance CYP3A2 activity in modified rat hepatocyte sandwich cultures
(Massachusetts Institute of Technology, 2007)
Isolated hepatocytes removed from their microenvironment soon lose their hepatospecific functions when cultured. Highly oxygen-demanding hepatocytes are commonly maintained under oxygen-deficient culture conditions, limited ...
Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
(Massachusetts Institute of Technology, 2008)
TLR-4 is essential in host defense against bacterial infection. By recognition of specific pathogen-associated molecular patterns such as lipopolysaccharide (LPS), TLR-4 can in tandem initiate a pair of downstream signaling ...
Design and in vitro development of resorbable urologic drug delivery device
(Massachusetts Institute of Technology, 2008)
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous ...
Virulence factors in non-gastric Helicobacters
(Massachusetts Institute of Technology, 1998)
The roles of diet and SirT3 levels in mediating signaling network changes in insulin resistance
(Massachusetts Institute of Technology, 2013)
The goal of my research is to understand the mechanism by which high fat diets mediate insulin sensitivity and the role SirT3 plays in high fat diet-induced insulin resistance. Insulin resistance is defined as the inability ...
The role of polyphosphate kinase in long term survival of Helicobacter pylori
(Massachusetts Institute of Technology, 1999)
Force-mediated adhesion strengthening in endothelial cells at adherens junctions
(Massachusetts Institute of Technology, 2007)
Cells respond to the application of force with a variety of biochemical responses modulating their shape, structure, function, and proliferation. Two force-responsive links between the inside and outside of a cell are ...
Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity
(Massachusetts Institute of Technology, 2007)
Idiosyncratic drug reactions are a subset of adverse reactions frequently targeting the liver, which become obvious only in large sample populations. Drug-induced hepatotoxicity, occurring in a very small fraction of ...
Investigating late stage biopharmaceutical product loss using novel analytical and process technology
(Massachusetts Institute of Technology, 2008)
The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments ...