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Developing a robust harvest for high cell density CHO cell culture
(Massachusetts Institute of Technology, 2020)
Process Improvement in Biotech : Dealing with High Complexity Processes
(Massachusetts Institute of Technology, 2009)
Across numerous conventional manufacturing sites, process improvement initiatives have been shown to increase production capabilities while decreasing costs - all without a required system- wide overhaul of the manufacturing ...
Investigating late stage biopharmaceutical product loss using novel analytical and process technology
(Massachusetts Institute of Technology, 2008)
The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments ...
Implementing lean methodologies within a maintenance organization
(Massachusetts Institute of Technology, 2009)
The primary goal of the project was to make the machine maintenance process more efficient. In order to do this, we conducted a 3-day Value Stream Mapping workshop, during which we generated a map of the present value ...
Streamlining and standardizing transcriptomic analysis in Amgen process development
(Massachusetts Institute of Technology, 2016)
Building biological understanding of the Chinese Hamster Ovary (CHO) system used to manufacture therapeutic proteins is paramount to efficient CHO bioprocess optimization. This understanding can be built by analyzing and ...
A computational framework for predicting CHO cell culture performance in bioreactors
(Massachusetts Institute of Technology, 2019)
Breaking the trade-off between speed and productivity is a key milestone across industries. In particular, in the biopharmaceutical industry this trade-off is exacerbated by a highly regulated environment, which hinders ...
Crystal ball planning for analytics implementation in Singapore
(Massachusetts Institute of Technology, 2014)
Amgen is building a new drug substance manufacturing site in Singapore (ASM). This project identified and mitigated the risks associated with implementing analytical technologies to facilitate the design and implementation ...