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Now showing items 21-30 of 33
A comparative analysis of diagnostic tools and techniques for manufacturing business support
(Massachusetts Institute of Technology, 2004)
The overriding objective of diagnostic assessment is change. Assessment processes are a mechanism to identify areas that merit change. In order to maximize the possibility that a company will adopt recommended changes ...
Analysis of variability in the semiconductor industry
(Massachusetts Institute of Technology, 2004)
While the pace of technical innovation in the semiconductor industry continues to accelerate, business processes and supply chain techniques have not kept up. Microprocessor performance improvement continues to follow ...
Optimization of preclinical profiling operations in drug discovery
(Massachusetts Institute of Technology, 2007)
In early-stage drug discovery, thousands of compounds must be tested using in vitro assays to determine their exposure and safety characteristics. This data is used to guide the selection of potential drug candidates and ...
Lean transformation methodology and implementation in biopharmaceutical operations
(Massachusetts Institute of Technology, 2008)
Amgen's Operations division is responsible for the production, release and distribution of commercial and clinical products. Due to industry consolidation, impending competition and revenue impacts, Amgen is facing the ...
Implementation of the new FDA quality by design guidance in pharmaceutical production
(Massachusetts Institute of Technology, 2008)
Due to the highly regulated environment, it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. ...
Critical process parameter determination during production start-up
(Massachusetts Institute of Technology, 2004)
Production start-up data is consistently utilized in a reactive manner during the initial stages of a product's lifecycle. However, if proactive information systems are created before full scale production starts, ramp-up ...
Control and optimization of E. coli picking process for DNA sequencing
(Massachusetts Institute of Technology, 2004)
As part of its responsibility to the National Institutes for Health, the sequencing operation at the Broad Institute strives for cost-effective production. This thesis attempts to reduce variability in the sequencing ...
Genome sequencing technology : improvement of the electrophoretic sequencing process and analysis of the sequencing tool industry
(Massachusetts Institute of Technology, 2005)
A primary bottleneck in DNA-sequencing operations is the capacity of the detection process. Although today's capillary electrophoresis DNA sequencers are faster, more sensitive, and more reliable than their precursors, ...
Design and operational enhancements for a batch process driven supply chain
(Massachusetts Institute of Technology, 2000)
Film manufacturing at Eastman Kodak involves large-scale batch steps dictated by both technical and economic factors. Large-scale batch processes can lead to an unresponsive and wasteful supply chain. This thesis explores ...
Process for evaluating options for materials management outsourcing
(Massachusetts Institute of Technology, 2004)
This thesis investigates the issues involved with the outsourcing of the materials management function within aerospace assembly, proposing a process for determining whether all or part of the responsibility should be given ...