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Biological detection by means of mass reduction in a suspended microchannel resonator
(Massachusetts Institute of Technology, 2004)
Label-free detection is the detection of biomolecules and their interactions, without the use of a molecule external to the interaction, used as a reporter to indicate presence and/or location. The suspended microchannel ...
High-throughput genomic phenotyping
(Massachusetts Institute of Technology, 2004)
In the wake of the development of technology to sequence the complete genome of an organism, it has become expedient to generate methodologies to elucidate and characterize the function of all genes constituting the complete ...
Investigation of growth factors and cytokines that suppress adult stem cell asymmetric cell kinetics
(Massachusetts Institute of Technology, 2005)
Adult stem cells are potentially useful in many biomedical applications that can save lives and increase the quality of a patient's life, such as tissue engineering, cell replacement, and gene therapy. However, these ...
Using optical tweezers, single molecule fluorescence and the ZIF268 protein-DNA system to probe mechanotransduction mechanisms
(Massachusetts Institute of Technology, 2006)
Optical tweezers instruments use laser radiation pressure to trap microscopic dielectric beads. With the appropriate chemistry, such a bead can be attached to a single molecule as a handle, permitting the application of ...
Molecular mechanism of interactions between estrogen receptor and estrogen receptor selective genotoxins
(Massachusetts Institute of Technology, 2000)
Although one million new breast cancer cases arise each year worldwide, therapies to treat the disease are limited. Conventional treatments including the chemotherapeutic agent, Tamoxifen, have had only limited success, ...
Distribution of mutant cells in human skin : exploration of the fetal-juvenile mutability hypothesis
(Massachusetts Institute of Technology, 2009)
The multiple "hits" carcinogenesis models are extensions of the cancer incidence theory developed by researchers from Nordling (1953), Armitage-Doll (1954 and 1957), Knudson (1971), Moolgavkar and Verzon (1979), to Moolgavkar ...
DNA alkylation repair deficient mice are susceptible to chemically induced Inflammatory Bowel Disease
(Massachusetts Institute of Technology, 2006)
The two most common forms of inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn's Disease (CD), which affect more than 1 million Americans. Recently the incidence of IBD has been rising in Japan, Europe ...
Process Improvement in Biotech : Dealing with High Complexity Processes
(Massachusetts Institute of Technology, 2009)
Across numerous conventional manufacturing sites, process improvement initiatives have been shown to increase production capabilities while decreasing costs - all without a required system- wide overhaul of the manufacturing ...
Quantitative analysis of TLR-4-mediated cell responses in murine macrophages
(Massachusetts Institute of Technology, 2008)
TLR-4 is essential in host defense against bacterial infection. By recognition of specific pathogen-associated molecular patterns such as lipopolysaccharide (LPS), TLR-4 can in tandem initiate a pair of downstream signaling ...
Investigating late stage biopharmaceutical product loss using novel analytical and process technology
(Massachusetts Institute of Technology, 2008)
The biopharmaceutical industry uses recombinant protein technologies to provide novel therapeutics to patients around the world. These technologies have presented exciting opportunities for breakthrough medical treatments ...