Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions
Author(s)
Feng, Sheng![Thumbnail](/bitstream/handle/1721.1/144930/Feng-shengf-phd-chemistry-2022-thesis.pdf.jpg?sequence=3&isAllowed=y)
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Advisor
Buchwald, Stephen L.
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The work described in this dissertation focuses on developing copper(I) hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. The third chapter demonstrates the enantioselective hydrocarbamoylation of alkenes enable by dual CuH and Pd catalysis.
Date issued
2022-05Department
Massachusetts Institute of Technology. Department of ChemistryPublisher
Massachusetts Institute of Technology