Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions

dc.contributor.advisor	Buchwald, Stephen L.
dc.contributor.author	Feng, Sheng
dc.date.accessioned	2022-08-29T16:21:45Z
dc.date.available	2022-08-29T16:21:45Z
dc.date.issued	2022-05
dc.date.submitted	2022-06-08T13:04:36.615Z
dc.identifier.uri	https://hdl.handle.net/1721.1/144930
dc.description.abstract	The work described in this dissertation focuses on developing copper(I) hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. The third chapter demonstrates the enantioselective hydrocarbamoylation of alkenes enable by dual CuH and Pd catalysis.
dc.publisher	Massachusetts Institute of Technology
dc.rights	In Copyright - Educational Use Permitted
dc.rights	Copyright MIT
dc.rights.uri	http://rightsstatements.org/page/InC-EDU/1.0/
dc.title	Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions
dc.type	Thesis
dc.description.degree	Ph.D.
dc.contributor.department	Massachusetts Institute of Technology. Department of Chemistry
dc.identifier.orcid	0000-0001-8781-9681
mit.thesis.degree	Doctoral
thesis.degree.name	Doctor of Philosophy