7.346 DNA Wars: How the Cell Strikes Back to Avoid Disease after Attacks on DNA, Fall 2013

Author(s)
Jordan, Jennifer; Nagel, Zachary
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Alternative title
DNA Wars: How the Cell Strikes Back to Avoid Disease after Attacks on DNA
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Abstract
A never-ending molecular war takes place in the nucleus of your cells, with DNA damage occurring at a rate of over 20,000 lesions per cell per day. Where does this damage come from, and what are its consequences? What are the differences in the molecular blueprint between individuals who can sustain attacks on DNA and remain healthy compared to those who become sick? This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Date issued
2013-12
URI
https://hdl.handle.net/1721.1/148318
Department
Massachusetts Institute of Technology. Department of Biology
Other identifiers
7.346-Fall2013
Other identifiers
7.346
IMSCP-MD5-47fedbe1663a80b3790271efb1839d4c
Keywords
DNA damage, DNA repair, mismatch repair, direct reversal, nucleotide excision repair, base excision repair, double strand break repair, nuclear DNA damage, mitochondrial DNA damage, Alkylating agents, replication errors, mutations, epigenetics, base excision repair, Werner helicase activity
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