| dc.contributor.author | Xue, Wen | |
| dc.coverage.temporal | Fall 2010 | |
| dc.date.accessioned | 2023-03-06T16:55:26Z | |
| dc.date.available | 2023-03-06T16:55:26Z | |
| dc.date.issued | 2010-12 | |
| dc.identifier | 7.344-Fall2010 | |
| dc.identifier.other | 7.344 | |
| dc.identifier.other | IMSCP-MD5-089477c751055d6d55ca7ff99268f142 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/148329 | |
| dc.description.abstract | Cancer is a leading cause of death worldwide. Cancer involves uncontrolled cell growth, resistance to cell death, failure to differentiate into a particular cell type, and increased cellular motility. A family of gate-keeper genes, known as tumor suppressor genes, plays important roles in preventing the initiation and progression of cancer. Among these, p53 is the most famous. Because of its essential role in maintaining genomic integrity, p53 is often called the guardian of the genome. During this course, we will study how p53 serves as a pivotal tumor suppressor gene in preventing cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. | en |
| dc.language.iso | en-US | |
| dc.rights | This site (c) Massachusetts Institute of Technology 2023. Content within individual courses is (c) by the individual authors unless otherwise noted. The Massachusetts Institute of Technology is providing this Work (as defined below) under the terms of this Creative Commons public license ("CCPL" or "license") unless otherwise noted. The Work is protected by copyright and/or other applicable law. Any use of the work other than as authorized under this license is prohibited. By exercising any of the rights to the Work provided here, You (as defined below) accept and agree to be bound by the terms of this license. The Licensor, the Massachusetts Institute of Technology, grants You the rights contained here in consideration of Your acceptance of such terms and conditions. | en |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 Unported | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | * |
| dc.subject | tumor suppressor gene | en |
| dc.subject | p53 | en |
| dc.subject | p53 protein | en |
| dc.subject | cancer | en |
| dc.subject | cell-growth signals | en |
| dc.subject | p53 protein | en |
| dc.subject | cell cycle regulation | en |
| dc.subject | DNA damage | en |
| dc.subject | DNA repair | en |
| dc.subject | programmed cell death | en |
| dc.subject | apoptosis | en |
| dc.subject | genome integrity | en |
| dc.subject | oncogenes | en |
| dc.subject | p53 mutations | en |
| dc.subject | mouse cancer models | en |
| dc.subject | Mdm2 | en |
| dc.subject | microRNA | en |
| dc.title | 7.344 Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer, Fall 2010 | en |
| dc.title.alternative | Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer | en |
| dc.audience.educationlevel | Undergraduate | |
| dc.subject.cip | 260911 | en |
| dc.date.updated | 2023-03-06T16:55:32Z | |
