7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation, Fall 2006

Author(s)
Guenther, Matthew; Kumar, Roshan
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Alternative title
Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation
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Abstract
In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Date issued
2006-12
URI
https://hdl.handle.net/1721.1/148342
Department
Massachusetts Institute of Technology. Department of Biology
Other identifiers
7.342-Fall2006
Other identifiers
7.342
IMSCP-MD5-efc79e0abb49c4e924553adb80435c86
Keywords
blueprint of life, transcription, stem cells, differentiation, human tissues, tissue regeneration, human disease, RNA and protein expression patterns, transcriptional regulation, specialized gene expression programs, genome, multipotent, terminally differentiated, pluripotency, master regulators, chromatin regulators, developmental defects, cancer
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