Non-pyrogenicity and biocompatibility of parylene-coated magnetic bead implants
Name
fbioe-12-1290453.pdf
Description
Published version
Size
1.39 MB
Format
Adobe PDF
Checksum (MD5)
6a3707a704dfb91ad04c398490317b26
Author(s)
Taylor, Cameron R
Nott, Joshua K
Ratnasena, Nilmini H
Cohen, Joel M
Herr, Hugh M
Date Issued
February 19, 2024
Journal
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Citation
Taylor CR, Nott JK, Ratnasena NH, Cohen JM and Herr HM (2024) Non-pyrogenicity and biocompatibility of parylene-coated magnetic bead implants. Front. Bioeng. Biotechnol. 12:1290453.
Version
Final published version
Abstract
Clinical grade magnetic bead implants have important applications in interfacing with the human body, providing contactless mechanical attachment or wireless communication through human tissue. We recently developed a new strategy, magnetomicrometry, that uses magnetic bead implants as passive communication devices to wirelessly sense muscle tissue lengths. We manufactured clinical-grade magnetic bead implants and verified their biocompatibility via intramuscular implantation, cytotoxicity, sensitization, and intracutaneous irritation testing. In this work, we test the pyrogenicity of the magnetic bead implants via a lagomorph model, and we test the biocompatibility of the magnetic bead implants via a full chemical characterization and toxicological risk assessment. Further, we test the cleaning, sterilization, and dry time of the devices that are used to deploy these magnetic bead implants. We find that the magnetic bead implants are non-pyrogenic and biocompatible, with the insertion device determined to be safe to clean, sterilize, and dry in a healthcare setting. These results provide confidence for the safe use of these magnetic bead implants in humans.
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3389/fbioe.2024.1290453
