Focal Brain Lesions Causing Acquired Amusia Map to a Common Brain Network
Name
e1922232024.full.pdf
Description
Published version
Size
2.44 MB
Format
Adobe PDF
Checksum (MD5)
47a4ca6e8dfda1d4592385193c4801f6
Author(s)
Sihvonen, Aleksi J
Ferguson, Michael A
Chen, Vicky
Soinila, Seppo
Särkämö, Teppo
Joutsa, Juho
Date Issued
April 10, 2024
Journal
The Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Aleksi J. Sihvonen, Michael A. Ferguson, Vicky Chen, Seppo Soinila, Teppo Särkämö, Juho Joutsa, Journal of Neuroscience 10 April 2024, 44 (15) e1922232024.
Version
Final published version
Abstract
Music is a universal human attribute. The study of amusia, a neurologic music processing deficit, has increasingly elaborated our view on the neural organization of the musical brain. However, lesions causing amusia occur in multiple brain locations and often also cause aphasia, leaving the distinct neural networks for amusia unclear. Here, we utilized lesion network mapping to identify these networks. A systematic literature search was carried out to identify all published case reports of lesion-induced amusia. The reproducibility and specificity of the identified amusia network were then tested in an independent prospective cohort of 97 stroke patients (46 female and 51 male) with repeated structural brain imaging, specifically assessed for both music perception and language abilities. Lesion locations in the case reports were heterogeneous but connected to common brain regions, including bilateral temporoparietal and insular cortices, precentral gyrus, and cingulum. In the prospective cohort, lesions causing amusia mapped to a common brain network, centering on the right superior temporal cortex and clearly distinct from the network causally associated with aphasia. Lesion-induced longitudinal structural effects in the amusia circuit were confirmed as reduction of both gray and white matter volume, which correlated with the severity of amusia. We demonstrate that despite the heterogeneity of lesion locations disrupting music processing, there is a common brain network that is distinct from the language network. These results provide evidence for the distinct neural substrate of music processing, differentiating music-related functions from language, providing a testable target for noninvasive brain stimulation to treat amusia.
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DOI of Published Version
https://doi.org/10.1523/JNEUROSCI.1922-23.2024
