Diamond rotors for high magic angle spinning frequencies
Name
nihms-2131284.pdf
Description
Accepted version
Size
1.94 MB
Format
Adobe PDF
Checksum (MD5)
7fd674e3095cf727499e3d0af03d28b2
Author(s)
Schaffer, Lauren
Preiss, David
Palani, Ravi Shankar
Wiesner, Nicholas
Liu, Jiaming
Strymish, Samuel
Bahri, Salima
Linse, Sara
Gershenfeld, Neil
Griffin, Robert G
Date Issued
October 2025
Journal
Journal of Magnetic Resonance
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
Magic Angle Spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy is limited in spectral resolution by the spinning frequency of rotors that hold the analyte. Traditional yttria-stabilized zirconia (YSZ) rotors have mechanical constraints that typically limit spinning frequencies of 0.7 mm rotors to ωr/2π ∼ 110 kHz. These frequencies are not sufficient to achieve resolution comparable to that of solution NMR, which theoretically requires ωr/2π > 300 kHz. Building upon prior work that utilized rotary-assisted drilling, we present significant advances in diamond rotor fabrication using a high precision lathe and a centerless laser machining fixture that achieves improved concentricity of the rotor outer and inner diameters and spinning stability. The new crop of diamond rotors, which interface with the Bruker MAS 3 spinning system equivalently or better than commercial rotors, were spun using automatic 0.7 mm profiles. Furthermore, diamond rotors can be emptied and repacked, and we describe a set of 3D-printed centrifuge tools for efficient execution of this process. We evaluate chemical vapor deposition (CVD) versus high-pressure high-temperature (HPHT) diamonds as rotor material and find HPHT preferable. Extended spin stability tests and multidimensional NMR spectra of Aβ1–40 demonstrate the robustness and usability of these rotors. These advances pave the way for higher frequency spinning with helium gas in the future, enabling transformative improvements in MAS NMR for biological and material sciences.
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Creative Commons Attribution-NonCommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.jmr.2025.107909
