Soluble Human Lectins at the Host–Microbe Interface
Name
annurev-biochem-062917-012322.pdf
Description
Published version
Size
6.55 MB
Format
Adobe PDF
Checksum (MD5)
880e286fa63276be3f2f4cfbd0839753
Author(s)
Peiffer, Amanda L
Dugan, AE
Kiessling, LL
Date Issued
April 19, 2024
Journal
Annual Review of Biochemistry
Publisher
Annual Reviews
Citation
Annu. Rev. Biochem. 2024. 93:565–601
Version
Final published version
Abstract
Human lectins are integral to maintaining microbial homeostasis on the skin, in the blood, and at mucosal barriers. These proteins can recognize microbial glycans and inform the host about its microbial status. In accordance with their roles, their production can vary with tissue type. They also can have unique structural and biochemical properties, and they can influence microbial colonization at sites proximal and distal to their tissue of origin. In line with their classification as innate immune proteins, soluble lectins have long been studied in the context of acute infectious disease, but only recently have we begun to appreciate their roles in maintaining commensal microbial communities (i.e., the human microbiota). This review provides an overview of soluble lectins that operate at host–microbe interfaces, their glycan recognition properties, and their roles in physiological and pathological mechanisms.
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Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1146/annurev-biochem-062917-012322
