Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging
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fcvm-07-00146.pdf
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7.27 MB
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Adobe PDF
Checksum (MD5)
2f6811e9fa617f05ba11b8aa27970588
Author(s)
Bouma, Brett
Otsuka, Kenichiro
Villiger, Martin
Nadkarni, Seemantini
Date Issued
August 28, 2020
Journal
Frontiers in Cardiovascular Medicine
Publisher
Frontiers Media SA
Citation
Otsuka K, Villiger M, Nadkarni SK and Bouma BE (2020) Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging. Front. Cardiovasc. Med. 7:146.
Version
Final published version
Abstract
Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) visualize the coronary artery wall and plaque morphology in great detail. The advent of these high-resolution intracoronary imaging modalities has propelled our understanding of coronary atherosclerosis and provided enhanced guidance for percutaneous coronary intervention. Yet, the lack of contrast between distinct tissue types and plaque compositions impedes further elucidation of the complex mechanisms that contribute to acute coronary syndrome (ACS) and hinders the prospective identification of plaques susceptible to rupture. Intravascular polarimetry with polarization-sensitive OFDI measures polarization properties of the coronary arterial wall using conventional intravascular imaging catheters. The quantitative polarization metrics display notable image contrast between several relevant coronary plaque microstructures that are difficult to identify with conventional OCT and OFDI. Tissues rich in collagen and smooth muscle cells exhibit birefringence, while lipid and macrophages cause depolarization. In this review, we describe the basic principles of intravascular polarimetry, discuss the interpretation of the polarization signatures, and outline promising avenues for future research and clinical implications.
Subjects
optical coherence tomography
polarimetry
atherosclerosis
collagen
smooth muscle cells
macrophage
neoatherosclerosis
drug-eluting stent
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3389/fcvm.2020.00146
