Total synthesis of complex 2,5-diketopiperazine alkaloids
Name
nihms-1971358.pdf
Description
Accepted version
Size
2.43 MB
Format
Adobe PDF
Checksum (MD5)
298519dcb5df47cb5fbd1b2e1d8d097a
Author(s)
Walker, Katherine L
Loach, Richard P
Movassaghi, Mohammad
Date Issued
2023
Journal
The Alkaloids: Chemistry and Biology
Publisher
Elsevier
Version
Author's final manuscript
Abstract
The 2,5-diketopiperazine (DKP) motif is present in many biologically relevant, complex natural products. The cyclodipeptide substructure offers structural rigidity and stability to proteolysis that makes these compounds promising candidates for medical applications. Due to their fascinating molecular architecture, synthetic organic chemists have focused significant effort on the total synthesis of these compounds. This review covers many such efforts on the total synthesis of DKP containing complex alkaloid natural products.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/bs.alkal.2023.06.002
