Computational studies on the factors influencing stabilities of collagen-like peptides

Author(s)
Chang, Nai-yuan, 1973-
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Massachusetts Institute of Technology. Dept. of Chemistry.
Advisor
Bernhardt L. Trout.
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Abstract
In this study, thermodynamic integration and molecular dynamics methods were used to elucidate the factors affecting stabilities of collagen-like peptides. We proposed to investigate three specific aspects: (1) the stabilizing effect of hydroxyproline (Hyp), (2) the destabilizing effect of replacing Gly, and (3) the role of water mediated hydrogen bonds. A better understanding of the origins of the stabilities of collagens will help in the design of new biomaterials and the treatment of collagen-related diseases.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.
 
Includes bibliographical references (leaf 26).
 
Date issued
2004
URI
http://hdl.handle.net/1721.1/28707
Department
Massachusetts Institute of Technology. Department of Chemistry
Publisher
Massachusetts Institute of Technology
Keywords
Chemistry.
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