| dc.contributor.advisor | Bernhardt L. Trout. | en_US |
| dc.contributor.author | Chang, Nai-yuan, 1973- | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Chemistry. | en_US |
| dc.date.accessioned | 2005-09-27T17:53:49Z | |
| dc.date.available | 2005-09-27T17:53:49Z | |
| dc.date.copyright | 2004 | en_US |
| dc.date.issued | 2004 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/28707 | |
| dc.description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004. | en_US |
| dc.description | Includes bibliographical references (leaf 26). | en_US |
| dc.description.abstract | In this study, thermodynamic integration and molecular dynamics methods were used to elucidate the factors affecting stabilities of collagen-like peptides. We proposed to investigate three specific aspects: (1) the stabilizing effect of hydroxyproline (Hyp), (2) the destabilizing effect of replacing Gly, and (3) the role of water mediated hydrogen bonds. A better understanding of the origins of the stabilities of collagens will help in the design of new biomaterials and the treatment of collagen-related diseases. | en_US |
| dc.description.statementofresponsibility | by Nai-yuan Chang. | en_US |
| dc.format.extent | 26 leaves | en_US |
| dc.format.extent | 1058316 bytes | |
| dc.format.extent | 1058598 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en_US | |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | |
| dc.subject | Chemistry. | en_US |
| dc.title | Computational studies on the factors influencing stabilities of collagen-like peptides | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | S.M. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | |
| dc.identifier.oclc | 59133389 | en_US |
