Algorithms for simulating human pre-mRNA splicing decisions

Author(s)
Rolish, Michael E. (Michael Edward)
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Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Advisor
Christopher B. Burge.
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Abstract
In this thesis, I developed a program, ExonScan, to simulate constitutive human pre-mRNA splicing. ExonScan includes several models for splicing components, including splice sites, exonic splicing enhancers, exonic splicing silencers, and intronic splicing enhancers. I used ExonScan to test various aspects of human splicing, including correlation of splicing signal strength with tissue expression levels, the effectiveness of experimentally determined exonic splicing silencers, and splice site identification.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
 
Includes bibliographical references (leaves 37-38).
 
Date issued
2005
URI
http://hdl.handle.net/1721.1/37066
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Publisher
Massachusetts Institute of Technology
Keywords
Electrical Engineering and Computer Science.
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