| dc.contributor.advisor | Christopher B. Burge. | en_US |
| dc.contributor.author | Rolish, Michael E. (Michael Edward) | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science. | en_US |
| dc.date.accessioned | 2007-04-03T17:08:01Z | |
| dc.date.available | 2007-04-03T17:08:01Z | |
| dc.date.copyright | 2005 | en_US |
| dc.date.issued | 2005 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/37066 | |
| dc.description | Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005. | en_US |
| dc.description | Includes bibliographical references (leaves 37-38). | en_US |
| dc.description.abstract | In this thesis, I developed a program, ExonScan, to simulate constitutive human pre-mRNA splicing. ExonScan includes several models for splicing components, including splice sites, exonic splicing enhancers, exonic splicing silencers, and intronic splicing enhancers. I used ExonScan to test various aspects of human splicing, including correlation of splicing signal strength with tissue expression levels, the effectiveness of experimentally determined exonic splicing silencers, and splice site identification. | en_US |
| dc.description.statementofresponsibility | by Michael E. Rolish. | en_US |
| dc.format.extent | 38 leaves | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | |
| dc.subject | Electrical Engineering and Computer Science. | en_US |
| dc.title | Algorithms for simulating human pre-mRNA splicing decisions | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | M.Eng. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | |
| dc.identifier.oclc | 82538091 | en_US |
