Vertical hydrodynamic focusing in an isotropically etched glass microfluidic device
Author(s)Lin, Tony An-tong
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Daniel E. Ehrlich and Anette Hosoi.
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The development of microfluidic devices has enabled precision control of nanoliter-scale environments and reactions. Vertical hydrodynamic focusing is one possible way to improve the optical performance of these devices while maintaining precision control. Vertical hydrodynamic focusing was studied through the use of computation fluid dynamics (ADINA) and experimental testing. It was found that the nonlinear effects of flow rate and geometry on the layering profile could be used to tune and correct the flow. A syringe pump-driven microfluidic device was fabricated out of isotropically etched and bonded glass plates and fluorescent confocal microscopy was used to verify computational models.
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.Includes bibliographical references (p. 107-109).
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology