Browsing MIT Open Access Articles by Author "Tabaka, Marcin"
Now showing items 1-6 of 6
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A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Baryawno, Ninib; Przybylski, Dariusz; Kowalczyk, Monika S.; Kfoury, Youmna; Severe, Nicolas; e.a. (Elsevier BV, 2019-06)Stroma is a poorly defined non-parenchymal component of virtually every organ with key roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma have defined individual populations in the stem ... -
Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq
Li, Bo; Gould, Joshua; Yang, Yiming; Sarkizova, Siranush; Tabaka, Marcin; e.a. (Springer Science and Business Media LLC, 2020)© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Massively parallel single-cell and single-nucleus RNA sequencing has opened the way to systematic tissue atlases in health and disease, but ... -
Cycling cancer persister cells arise from lineages with distinct programs
Oren, Yaara; Tsabar, Michael; Cuoco, Michael S; Amir-Zilberstein, Liat; Cabanos, Heidie F; e.a. (Springer Science and Business Media LLC, 2021)Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure1, where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment2. Although most cancer ... -
Enforcement of developmental lineage specificity by transcription factor Oct1
Shen, Zuolian; Kang, Jinsuk; Shakya, Arvind; Tabaka, Marcin; Jarboe, Elke A; e.a. (eLife Sciences Publications, Ltd, 2017-05)Embryonic stem cells co-express Oct4 and Oct1, a related protein with similar DNA-binding specificity. To study the role of Oct1 in ESC pluripotency and transcriptional control, we constructed germline and inducible-conditional ... -
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function
Tang, Ruihan; Acharya, Nandini; Subramanian, Ayshwarya; Purohit, Vinee; Tabaka, Marcin; e.a. (American Association for the Advancement of Science (AAAS), 2022)<jats:p>Dendritic cells (DCs) sense environmental cues and adopt either an immune-stimulatory or regulatory phenotype, thereby fine-tuning immune responses. Identifying endogenous regulators that determine DC function can ... -
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses
Xu, Heping; Ding, Jiarui; Porter, Caroline; Wallrapp, Antonia; Tabaka, Marcin; e.a. (Elsevier BV, 2019-10)Signaling abnormalities in immune responses in the small intestine can trigger chronic type 2 inflammation involving interaction of multiple immune cell types. To systematically characterize this response, we analyzed ...