3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform

Author(s)
Jeon, Jessie Sungyun
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Alternative title
Three-dimensional cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Other Contributors
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Advisor
Joseph Charest and Roger Kamm.
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Abstract
A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.
 
Cataloged from PDF version of thesis.
 
Includes bibliographical references (p. 48-51).
 
Date issued
2010
URI
http://hdl.handle.net/1721.1/61871
Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Publisher
Massachusetts Institute of Technology
Keywords
Mechanical Engineering.
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