3D cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Author(s)Jeon, Jessie Sungyun
Three-dimensional cyclic olefin copolymer (COC) microfluidic chip fabrication using hot embossing method for cell culture platform
Massachusetts Institute of Technology. Dept. of Mechanical Engineering.
Joseph Charest and Roger Kamm.
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A microfluidic system has been developed for studying the factors inducing different responses of cells in vascular system using a three-dimensional microenvironment. The devices have been transferred from PDMS to a platform in cyclic olefin copolymer (COC) which has advantages in terms of hydrophobicity, production by the more commercially-viable hot embossing technique, and amenability to surface treatments. Here the fabrication process is described and the new systems are characterized. Surface wettability, bond strength between the system body and a covering plastic film, and cell viability data are presented and compared to systems fabricated in PDMS.
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 48-51).
DepartmentMassachusetts Institute of Technology. Dept. of Mechanical Engineering.; Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology