Browsing MIT Theses by Title
Now showing items 24548-24567 of 61793
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Functional dissection of the S. cerevisiae helicase activating factor Cdc45
(Massachusetts Institute of Technology, 2013)Eukaryotic DNA replication initiation requires two essential steps: helicase loading and activation. During the G1 to S transition, loaded Mcm2-7 helicases are activated by the S-CDK (S phase cyclin-dependent kinase)- and ... -
Functional DNA repair capacity assays : a focus on base excision repair
(Massachusetts Institute of Technology, 2016)The integrity of our DNA is challenged by roughly 100,000 lesions per cell on a daily basis. Failure to cope with DNA damage can lead to cancer, immunodeficiency and degenerative disease. Quantitating and understanding an ... -
Functional encapsulation and type reconstruction in a strongly-typed, polymorphic language
(Massachusetts Institute of Technology, 1995) -
A functional flow framework for cloud computing
(Massachusetts Institute of Technology, 2012)This thesis covers a basic framework to calculate the maximum computation rate of a set of functions over a network. These functions are broken down into a series of computations, which are distributed among nodes of the ... -
Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
(Massachusetts Institute of Technology, 2016)Chemotherapy for the treatment of systemic cancer originated over half a century ago. Thus, many of our most successful therapies were implemented clinically without the wealth of molecular and genetic knowledge we have ... -
Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
(Massachusetts Institute of Technology, 2023-09)Biology is driven by complex cellular processes that require precise regulation in time and in space. However, the genetic and molecular factors underlying these behaviors are difficult to study in their native contexts ... -
Functional genomics of a non-toxic Alexandrium lusitanicum culture
(Massachusetts Institute of Technology, 2007)Paralytic shellfish poisoning (PSP) is a human intoxication associated with the consumption of shellfish contaminated with a family of neurotoxins called saxitoxins. Many species in the dinoflagellate genus Alexandrium ... -
Functional integration applied to the nuclear many body-problem
(Massachusetts Institute of Technology, 1982) -
A functional inverse approach for three-dimensional characterization of subsurface contamination
(Massachusetts Institute of Technology, 1996) -
Functional large non-coding RNAs in mammals
(Massachusetts Institute of Technology, 2012)It is now clear that RNA is more than a messenger and performs vast and diverse functions. These functional RNAs include the ribosomal, transfer, and splicing-associated RNAs along with a cast of tiny RNAs, including ... -
Functional lung imaging in humans using Positron Emission Tomography
(Massachusetts Institute of Technology, 2003)This thesis deals with a method of functional lung imaging using Positron Emission Tomography (PET). In this technique, a radioactive tracer, nitrogen-13, is dissolved in saline solution, and injected into a peripheral ... -
Functional magnetic resonance imaging of the frequency organization of human auditory cortex
(Massachusetts Institute of Technology, 1998) -
Functional measurements of ear pathology in patients and cadaveric preparations
(Massachusetts Institute of Technology, 2014)This work investigated the utility of reflectance (R), a measure of middle-ear mobility, in the differential diagnosis of pathologies responsible for conductive hearing loss (CHL). Current clinical practice cannot distinguish ... -
The functional microRNA landscape of mammalian development
(Massachusetts Institute of Technology, 2011)MicroRNAs (miRNAs) constitute a class of ~22 nucleotide RNAs with broad regulatory roles in gene expression. Dependent largely on the enzyme Dicer for their generation from longer precursor transcripts, mammalian miRNAs ... -
Functional miRNA regulation of metastatic genes promotes tumor cell dissemination in non-small cell and small cell lung carcinomas
(Massachusetts Institute of Technology, 2013)Tumor progression, from initiation to advanced metastatic disease, requires the orchestration of a diverse group of cell-intrinsic and extrinsic factors. This multifactorial disease is promoted by an accumulation of genetic ... -
Functional modularity in gene networks
(Massachusetts Institute of Technology, 2016)This thesis addresses two sources of context-dependence in both systems and synthetic biology: retroactivity and competition for shared cellular resources. The contribution is the development of simple-to-use computational ... -
A functional MRI study of the distributed neural circuitry of learning and reward
(Massachusetts Institute of Technology, 2005)The aim of this research project was to study the neural substrates involved in processing rewarding stimuli. Evaluation of the magnitudes of reward is one of the fundamental aspects of goal directed behavior, and studies ... -
Functional multilayer organic thin films fabricated by layer-by-layer sequential adsorption technique
(Massachusetts Institute of Technology, 1997) -
Functional organization of the human superior temporal sulcus
(Massachusetts Institute of Technology, 2016)As we observe and listen to other people, we interpret their actions in terms of a rich causal structure, driven by underlying mental states and dispositional traits. The ability to rapidly extract abstract social information ... -
The functional perspective of financial innovation and real estate
(Massachusetts Institute of Technology, 2004)Two broad schools of thought dominate theories regarding financial innovation. One seeks to explain the process of security design in terms of relatively static organizations creating and promoting their wares and services ...
