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Now showing items 31-40 of 41
Lean transformation methodology and implementation in biopharmaceutical operations
(Massachusetts Institute of Technology, 2008)
Amgen's Operations division is responsible for the production, release and distribution of commercial and clinical products. Due to industry consolidation, impending competition and revenue impacts, Amgen is facing the ...
Implementation of the new FDA quality by design guidance in pharmaceutical production
(Massachusetts Institute of Technology, 2008)
Due to the highly regulated environment, it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. ...
Analysis of email and phone queuing systems in a world-wide contact center network
(Massachusetts Institute of Technology, 2008)
Contact centers are operated by companies to answer customer inquiries via phone calls or email. Customers often equate the service they are provided while interacting with a contact center to the quality of a company's ...
Creating a sustaining value engineering function within worldwide manufacturing
(Massachusetts Institute of Technology, 2008)
Most product cost reduction in industry occurs during new product introduction (NPI). However, for some firms, a case can be made that product cost reduction efforts can be devoted towards products already in sustained ...
Tailoring the prototyping process to achieve customer value
(Massachusetts Institute of Technology, 2008)
The main objective for prototyping is to get the most value out of the opportunity. Value may take the form of information, performance, displaying production readiness or proving capability for the amount of resources ...
Evaluation of drying technologies for storage and shipment of recombinant protein drug substance
(Massachusetts Institute of Technology, 2008)
With growing markets and increasing pipelines, biotechnology companies face a supply chain challenge to manufacture and distribute products using economically feasible methods that protect protein integrity. Adequate storage ...
The role of assessment in a lean transformation
(Massachusetts Institute of Technology, 2008)
When starting the journey to become a Lean company, companies commonly face the problem of understanding how to manage a Lean transformation. Often times, the first step in managing a Lean transformation is to understand ...
Supply chain strategy for a compressed flow-time retrofitting manufacturing process
(Massachusetts Institute of Technology, 2008)
In today's competitive environment, a compressed flow-time enables companies to present a strong value proposition especially for products with a high asset value. In a retrofitting manufacturing process the state of ...
Improving producibility in aerospace engine manufacturing : process automation vs. process reengineering
(Massachusetts Institute of Technology, 2008)
In any aerospace manufacturing operation, including Pratt & Whitney's Compression Systems Module Center, producibility problems can be major drivers of cost. Much of the literature focuses on design for manufacturability ...
Innovation enabling manufacturing processes
(Massachusetts Institute of Technology, 2008)
Global operations for multinational companies today pose a particularly challenging environment for maintaining fluid knowledge transfer and effective communication methodologies. In a continuous drive for product innovation, ...