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Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction
(Massachusetts Institute of Technology, 2008)
The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis ...
High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling
(Massachusetts Institute of Technology, 2008)
The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...
Non-invasive detection of oral cancer using reflectance and fluorescence spectroscopy
(Massachusetts Institute of Technology, 2008)
In vivo reflectance and fluorescence spectra were collected from patients with oral lesions, as well as healthy volunteers, in order to evaluate the potential of spectroscopy to serve as a non-invasive tool for the detection ...
Cellular and molecular immunotherapeutics derived from the bone marrow stroma
(Massachusetts Institute of Technology, 2008)
The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration ...
Analysis of nonmodal glottal event patterns with application to automatic speaker recognition
(Massachusetts Institute of Technology, 2008)
Regions of phonation exhibiting nonmodal characteristics are likely to contain information about speaker identity, language, dialect, and vocal-fold health. As a basis for testing such dependencies, we develop a representation ...
Proxy genotypes and phenotypes for human genetics
(Massachusetts Institute of Technology, 2008)
Genetic mapping by association is an unbiased approach to discover genes and pathways influencing disease traits and response to drugs and environmental exposures. There are two key obstacles to mapping in humans: (1) The ...
Characterizing monitoring for the diagnosis and resuscitation of shock patients
(Massachusetts Institute of Technology, 2008)
Many factors contribute to a company's decision to launch a product in a new market. The company must be able to identify a clinical need that the product will address and the market must be willing to pay for the new ...
Privacy and identifiability in clinical research, personalized medicine, and public health surveillance
(Massachusetts Institute of Technology, 2008)
Electronic transmission of protected health information has become pervasive in research, clinical, and public health investigations, posing substantial risk to patient privacy. From clinical genetic screenings to publication ...
Likelihood and Bayesian signal processing methods for the analysis of auditory neural and behavioral data
(Massachusetts Institute of Technology, 2008)
Developing a consensus on how to model neural and behavioral responses and to quantify important response properties is a challenging signal processing problem because models do not always adequately capture the data and ...
Coil performance evaluation based on electrodynamics : tools for hardware design and validation in magnetic resonance imaging
(Massachusetts Institute of Technology, 2008)
Parallel MRI techniques allow acceleration of MR imaging beyond traditional speed limits. In parallel MRI, radiofrequency (RF) detector coil arrays are used to perform some degree of spatial encoding which complements ...