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Opportunities and challenges in oncology targeted drug development : an assessment of the use of prevalence and companion diagnostic performance thresholds to guide clinical trial strategies
(Massachusetts Institute of Technology, 2012)
Targeted, especially stratified or biomarker-guided, therapies offer significant advantages over traditional oncology therapies in certain settings. Selecting patients most likely to respond to a drug increases the therapeutic ...
Understanding the drivers of value creation for biopharmaceuticals around the time of drug launch
(Massachusetts Institute of Technology, 2012)
The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market ...
The contribution of disease focused nonprofits to biomedical research and development
(Massachusetts Institute of Technology, 2013)
Patient-centered, disease-focused nonprofits are playing an increasingly prominent role in accelerating the development of new diagnostics, drugs, and therapies. They are engaging in a variety of complex venture philanthropic ...
Disease marketing and patient coping : a research study
(Massachusetts Institute of Technology, 2012)
BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...
Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease
(Massachusetts Institute of Technology, 2007)
Vaso-occlusive crises cause most of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however ...
Genomics research and cultivating serendipity in pharmaceutical drug discovery : assessing the competitiveness of R&D productivity between the West and Asia
(Massachusetts Institute of Technology, 2007)
It has been widely reported that pharmaceutical drug discovery innovation began its major decline somewhere in the last decade of the 20th century. After reaching a historical high of 53 new molecular entities (NMEs) in ...
Green fluorescent protein as a mechanical sensor
(Massachusetts Institute of Technology, 2007)
Inquiry into intracellular and cytoskeletal mechanics requires an intracellular mechanical sensor to verify models of sub-cellular structure dynamics. To this end, the green fluorescent protein (GFP) is considered as a ...
Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction
(Massachusetts Institute of Technology, 2008)
The skin microcirculation performs a range of vital functions, such as maintaining nutritional perfusion to the tissues and overall thermoregulation. Not only does impairment to the skin blood supply lead to tissue necrosis ...
Development of a chronically implanted microelectrode array for intraneural electrical stimulation for prosthetic sensory feedback
(Massachusetts Institute of Technology, 1999)
The functionality of prosthetic limbs is restricted by the limited availability of sensory feedback. This research aims to develop a technology to allow the presentation of sensory information directly to the sensory ...
Emerin and inherited disease
(Massachusetts Institute of Technology, 2004)
(cont.) nucleus and at the nuclear surface.