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Robust model invalidation for chemical reaction networks using generalized moments (extended version)
(2023-03-31)
Many biomolecular systems can be described by chemical reaction networks. Determining which chemical reaction network models are inconsistent with observed data can be done via model invalidation. In this work, we formulate ...
An N-stage Cascade of Phosphorylation Cycles as an Insulation Device for Synthetic Biological Circuits
(2016-03-27)
Single phosphorylation cycles have been found to have insulation device abilities, that is, they attenuate the effect of retroactivity applied by downstream systems and hence facilitate modular design in synthetic ...
Time-scale separation based design of biomolecular feedback controllers (extended version)
(2019-03-14)
Time-scale separation is a powerful property that can be used to simplify control systems design. In this work, we consider the problem of designing biomolecular feedback controllers that provide tracking of slowly varying ...
Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action - Extended Version
(2024-03-21)
In the context of epigenetic transformations in cancer metastasis, a puzzling effect was recently discovered, in which the elimination (knock-out) of an activating regulatory element leads to increased (rather than decreased) ...