7.344 Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer, Fall 2010

Author(s)
Xue, Wen
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Tumor Suppressor Gene p53: How the Guardian of our Genome Prevents Cancer
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Abstract
Cancer is a leading cause of death worldwide. Cancer involves uncontrolled cell growth, resistance to cell death, failure to differentiate into a particular cell type, and increased cellular motility. A family of gate-keeper genes, known as tumor suppressor genes, plays important roles in preventing the initiation and progression of cancer. Among these, p53 is the most famous. Because of its essential role in maintaining genomic integrity, p53 is often called the guardian of the genome. During this course, we will study how p53 serves as a pivotal tumor suppressor gene in preventing cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Date issued
2010-12
URI
https://hdl.handle.net/1721.1/148329
Other identifiers
7.344-Fall2010
Other identifiers
7.344
IMSCP-MD5-089477c751055d6d55ca7ff99268f142
Keywords
tumor suppressor gene, p53, p53 protein, cancer, cell-growth signals, p53 protein, cell cycle regulation, DNA damage, DNA repair, programmed cell death, apoptosis, genome integrity, oncogenes, p53 mutations, mouse cancer models, Mdm2, microRNA
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