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SES #  TOPICS READINGS 1 Introduction The Black e-Bag Required Readings: Rainie, L., T. Spooner, B. Kalsnes, and S. Nof. "The Dot-Com Meltdown and the Web." Pew Internet & American Life Project. Fox, S., and L. Rainie. Vital Decisions: How Internet Users Decide what Information to Trust when they or their loved ones are sick. Pew Internet & American Life Project. 2002. 2 The Future of Healthcare IT Ventures Required Readings: Case Study: WebMD by: Peter J. Coughlan; Michael G. Rukstad; Carl Johnston. Harvard Business School Publication; Product Number:9-701-007. Recommended Readings: Lewis, M. The New New Thing: A Silicon Valley Story. New York: W. W. Norton, 2000. Werth, B. The Billion-Dollar Molecule: One Company's Quest for the Perfect Drug. New York: Simon & Schuster, 1994. Moore, G. A., and R. McKenna. Crossing the Chasm: Marketing and Selling High-Tech Products to Main Stream Customers. New York: Harper Business, 1999. 3 The Future of EPR and the E-Empowered Patient Required Readings: Sands, D. Z., J. D. Halamka, and D. Pellaton. Patient Site: A Web-Based Clinical Communication and Health Education Tool. Savas, S. D. Health-e Opportunities in e-Health? Goldman Sachs. November 11, 1999. Safran, C., D. Rind, and R. B. Davis, et al. Implementing Practice Guidelines within a Knowledge Based Medical Record. 1993. "Electronic Patient Centered Communication Resource Center." http://www.e-pcc.org Kassirer, J. P. "The Next Transformation in the Delivery of Health Care." NEJM 332, 1: 52-53. MacDonald, K., J. Case, and J. Metzger. E-Encounters. 2001. Cain, M., R. Mittman. Diffusion of Innovation in Health Care. 4 Innovation and the Power of Disruptive Technology in Healthcare Required Readings: A Brief Commentary on Disruptive Innovation in Healthcare: U.S. Senate Committee on Commerce, Science, and Transportation. Testing the Limits of Innovation. SpencerStuart Directors' Breakfast Series. Rigby, D., C. Zook. "Open-Market Innovation." Harvard Business Review (October 2002). 5 The Future of Biodefense and IT Required Readings: Mandl, K. D. Infrastructure and Methods to Support Real Time Biosurveillance. Lober, W. B., B. T. Karras, and M. M. Wagner, et al. "Roundtable on Bioterrorism Detection: Information System-based Surveillance." Journal of the American Informatics Association 9, 2 (2002): 105-115. Goldenberg, A., G. Shmueli, R. A. Caruana, and S. E. Fienberg. "Early Statistical Detection of Anthrax Outbreaks by Tracking Over-the-Counter Medication Sales." PNAS 99, 8 (2002): 5237-5240. Reis, B. Y., and K. D. Mandl."Time Series Modeling for Syndromic Surveillance." BMC Medical Informatics and Decision Making. 2003. Reis, B. Y., M. Pagano, and K. D. Mandl. "Using Temporal Context to Improve Biosurveillance." PNAS 100, 4: 1961-1965. 6 The Future of Healthcare Enterprise Computing Required Readings: Glaser, J., and C. Bero. "Commentary: Connecting Health and Healthcare." Strengthening Organizational Performance of Academic Health Centers. Edited by D. Detmer and E. Steen. Cambridge University Press, In Press. Glaser, J. "Lessons Learned: Implementing a Clinical Information Systems can Offer a Rich Education." Healthcare Informatics (Sept. 2002): 39-40. ------. "Experiences with Knowledge Application in Medical Care." Journal of Healthcare Information Management 16, 3 (2002): 23-29. ------. "Integration of Information Systems at Partners HealthCare System." MD Computing 17, 5 (Sept/Oct. 2000): 23-28. 7 Simulation Laboratory/Field Trip 8 The Future of Genomics and Informatics Required Readings: "Distinct Types of Diffuse Large B Cell Lymphoma Identified by Gene Expression Profiling." Nature (2000). "Discovering Functional Relationships Between RNA Expression and Chemotherapeutic Susceptibility Using Relevance Networks." PNAS (2000). "Interpreting Patterns of Gene Expression with Self-organizing Maps: Methods and Application to Hematopoietic Differentiation." PNAS (1999). 9 Challenges in Implementing Bioinformatics Solutions Summary: Bioinformatics is advancing the new field of Clinical Genomics by providing the tools and the technologies used to bridge the gap between molecular biology and clinical medicine. These leading edge tools and processes will continue to facilitate the discovery of a new generation of safer and more effective therapeutics. Required Readings: Palfreyman, M., C. Vinod, and J. Blander. "The Importance of Using Human Based Models in Gene and Drug Discovery." Drug Discovery World (Fall 2002). 10 The Future of Academic Computing Required Readings: "PatientSite: A Web-based Clinical Communication and Health Education Tool." 11 The Future of Disease Management Required Readings: Bodenheimer, T. "Disease Management - Promises and Pitfalls." NEJM 340, 15 (April 15, 1999): 1202-5. Meigs, J. B., E. Cagliero, A. Dubey, P. Murphy-Sheehy, C. Gildesgame, H. Chueh, M. J. Barry, D. E. Singer, and D. M. Nathan. "A Controlled Trial of Web-based Diabetes Disease Management: The MGH Diabetes Primary Care Improvement Project." Diabetes Care 26, 3 (Mar. 2003): 750-7. Adomeit, A., A. Baur, and R. Salfeld. "A New Model for Disease Management." McKinsey Quarterly. Leider, H. L. "Gaining Physician Buy-In for Disease Management Initiatives." Disease Management Health Outcomes 6, 6 (Dec. 1999): 327-333. ------. "Selecting a Vendor for Disease Management Programs." Disease Management Health Outcomes 6, 13 (1999): 131-9. Recommended Readings: Wagner, E., and C. Davis, et al. "A Survey of Leading Chronic Disease Management Programs: Are They Consistent with the Literature?" Managed Care Quarterly 7, 3 (1999): 60-70. Herzlinger, R. E. Market Driven Health Care. Reading (MA): Addison-Wesley Publishing, 1997. Kozma et al. "A Model for Comprehensive Disease State Management." The Journal of Outcomes Management. (Feb. 1997): 4-8. 12 Review and Wrap-up 13 Final Presentations 14 Final Presentations