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Now showing items 11-20 of 41
Mapping the therapy resistance landscapes of acute leukemias using in vivo functional genomics
(Massachusetts Institute of Technology, 2020)
The recurrence of therapy resistant disease remains an intractable problem in oncology clinical care. To address this issue, investigators have traditionally focused on elucidating cell-intrinsic mechanisms that render ...
Activin signaling controls a wound-induced program essential for regenerative patterning
(Massachusetts Institute of Technology, 2020)
A central problem in animal regeneration is how animals determine what body part to regenerate. Planarians are flatworms that can regenerate any missing body part, and are studied to identify mechanisms underlying regeneration. ...
Structural and functional investigations of mechanisms of iron-utilizing enzymes
(Massachusetts Institute of Technology, 2020)
Biological systems use iron as a key cofactor to catalyze a variety of difficult chemical transformations, particularly as reservoirs from which to initiate enzymatic radical chemistry. Here, I discuss efforts to study the ...
A nanobody suite for yeast scaffold nucleoporins provides details of the Y complex structure and nuclear pore complex assembly
(Massachusetts Institute of Technology, 2020)
Nuclear pore complexes (NPCs) are the main conduits for molecular exchange across the nuclear envelope. The NPC is a modular assembly of ~500 individual proteins, called nucleoporins or nups, that can be classified into ...
Structural characterization of glycyl radical enzymes in the human gut microbiome
(Massachusetts Institute of Technology, 2020)
Anaerobic bacteria play important roles in the human gut microbiome and have dedicated chemical pathways for growth in the absence of oxygen. Glycyl radical enzymes (GREs) use an oxygen-sensitive glycyl radical cofactor ...
Functions of alternative ClpP subunits in Pseudomonas aeruginosa
(Massachusetts Institute of Technology, 2020)
Proteolysis is the process by which proteins are broken down, or hydrolyzed, into small peptides or amino acids by enzymes. Cells from all forms of life carry out regulated protein degradation as a way to control cellular ...
Intersubunit communication and coordinated mechanical activity in the AAA+ protease ClpXP
(Massachusetts Institute of Technology, 2020)
Proteases belonging to the AAA+ (ATPases associated with various cellular activities) family perform regulated proteolysis in all domains of life by binding, mechanically unfolding, and degrading target proteins. The ...
The spatial organization of the microtubule cytoskeleton and cell divisions promotes tissue morphogenesis
(Massachusetts Institute of Technology, 2020)
During embryonic development, epithelial tissues grow and become sculpted into complex shapes through highly coordinated cell behaviors, such as cell shape change and cell division. Both processes involve contractile forces ...
Keep the ORCs at bay : how eukaryotic cells ensure one round of DNA replication per cell cycle
(Massachusetts Institute of Technology, 2020)
During each cell cycle, eukaryotic cells must faithfully replicate their genome, ensuring exactly one full copy is made. Both under-replicating or over-replicating the genome can have deleterious consequences including ...
Molecular mediators of cardiac-specific enhancer activation
(Massachusetts Institute of Technology, 2020)
Understanding how transcription factors (TFs) control gene expression programs is critical for determining the genetic pathways responsible for development. Heart development is particularly sensitive to precise control ...